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GSK 343

Catalog #: 6128
1 Citation Datasheet / COA / SDS
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6128/50
6128/10
GSK 343 | CAS No. 1346704-33-3 | EZH2 Inhibitor
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Description: Potent and selective SAM-competitive EZH2 inhibitor

Chemical Name: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GSK 343 is a potent and selective SAM-competitive EZH2 inhibitor (IC50 = 4 nM), that exhibits >60 fold selectivity for EZH2 over EZH1 and a range of other methyltransferases. GSK 343 decreases H3K27me3 levels in breast cancer cells and inhibits proliferation of prostate cancer cell lines in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 343 is reviewed on the chemical probes website.

Technical Data

M.Wt:
541.69
Formula:
C31H39N7O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1346704-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK343 probe summary on the SGC website.

Product Datasheets

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Citation for GSK 343

The citations listed below are publications that use Tocris products. Selected citations for GSK 343 include:

1 Citation: Showing 1 - 1

  1. A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma.
    Authors: Karin Et al.
    Cell Death Dis  2021;12:167

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