GR 64349

Catalog #: 1668
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1668/1

1 Image

Description: Potent, selective NK2 agonist

Purity: ≥95%

View All Products for NK2 Receptor Agonists

Product Details

Citations (3)

Supplemental Products

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GR 64349 is a potent and selective tachykinin NK₂ receptor agonist (EC₅₀ = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK₁ and NK₃ receptors respectively. Active in vivo.

Technical Data

M.Wt:

921.12

Formula:

C₄₂H₆₈N₁₀O₁₁S

Sequence:

KDSFVGLM

(Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

137593-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from GlaxoSmithKline

Background References

Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
Deal et al.
J.Med.Chem., 1992;35:4195
Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A.
Chang et al.
J.Pharmacol.Exp.Ther., 2000;294:147
Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK₁ and NK₂ receptors in the rat spinal cord.
Chizh et al.
Br.J.Pharmacol., 1995;115:1013

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for GR 64349

The citations listed below are publications that use Tocris products. Selected citations for GR 64349 include:

3 Citations: Showing 1 - 3

Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity.
Authors: León Et al.
Sci.Rep. 2016;6:19206
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
Authors: Navarro Et al.
Sci Rep 2015;156:627
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Authors: Ruiz-Pino Et al.
Endocrinology 2015;156:576

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for GR 64349

There are currently no reviews for this product. Be the first to review GR 64349 and earn rewards!

Have you used GR 64349?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.