GR 144053 trihydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. GpIbalpha-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.
   Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, Guillou S, Denis C, Maubert E, Orset C, Vivien D
   Blood, 2014;123(21):3354-63.
3. Gq pathway regulates proximal C-type lectin-like receptor 2 (CLEC-2) signaling in platelets
   R Badolia, V Inamdar, BK Manne, C Dangelmaie, SP Kunapuli
   J. Biol. Chem., 2017;0(0):.
4. Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent.
   Eldred et al.
   J.Med.Chem., 1994;37:3882
5. GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster.
   Matsuno et al.
   Br.J.Pharmacol., 1997;122:1099
6. Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates.
   Matsuno et al.
   Br.J.Pharmacol., 1999;127:1129
7. Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy.
   M Y Lee, C C Verni, B A Herbig, S L Diamond
   Journal of Thrombosis and Haemostasis : Jth, 2017;0(0):1538-7836.
8. Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation
   D Puhr-Weste, SJ Schink, M Fabritius, L Mittmann, MET Hessenauer, J Pircher, G Zuchtriege, B Uhl, M Holzer, S Massberg, F Krombach, CA Reichel
   Sci Rep, 2019;9(1):15932.

Product Datasheets