GKA 50
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Purity: ≥98%
Biological Activity
GKA 50 is a potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.
Coope et al.
Br.J.Pharmacol., 2006;149:328 -
Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells.
Johnson et al.
Biochem.Soc.Trans., 2007;35:1208
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