Genistein

Biological Activity

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ₄₂ and amylin₃₇ (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
   Tollefson and Taylor
   CNS Drug Reviews, 2000;6:303
3. Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides.
   Ren et al.
   ACS.Chem.Neurosci., 2018;9:1215
4. Genistein, a specific inhibitor of tyrosine-specific protein kinases.
   Akiyama et al.
   J.Biol.Chem., 1987;262:5592
5. Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein.
   Dang et al.
   J.Biol.Chem., 2003;278:962
6. Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity.
   Linassier et al.
   Biochem.Pharmacol., 1990;39:187
7. Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.
   Migita et al.
   J.Immunol., 1994;153:3457
8. Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients.
   Pierzynowska et al.
   Metab.Brain Dis., 2019;34

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