Galloflavin
Chemical Name: 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
Purity: ≥95%
Biological Activity
Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.
Manerba et al.
ChemMedChem, 2012;7:311 -
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.
Fiume et al.
Biochem.Biophys.Res.Commun., 2013;430:466 -
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.
Farabegoli et al.
Eur.J.Pharm.Sci., 2012;47:729
Product Datasheets
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Citations for Galloflavin
The citations listed below are publications that use Tocris products. Selected citations for Galloflavin include:
2 Citations: Showing 1 - 2
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Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells.
Authors: Dietmar Et al.
Anticancer Res 2020;40:153-160
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Nature 2016;539:390
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