GABA
Chemical Name: γ-Aminobutyric acid
Biological Activity
GABA is a GABA receptor agonist and endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
T Pérez-Bere, J Pujo, P Martin, P Le Faouder, JM Galano, A Guy, C Knauf, JC Tabet, S Tronnet, F Barreau, M Heuillet, G Dietrich, J Bertrand-M, T Durand, E Oswald, N Cenac
Nat Commun, 2017;8(1):1314. -
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis
M Diepenbruc, S Tiede, M Saxena, R Ivanek, RKR Kalathur, F Lüönd, N Meyer-Scha, G Christofor
Nat Commun, 2017;8(1):1168. -
GABA, bicuculline and central inhibition.
Curtis et al.
Nature, 1970;226:1222 -
GABA: a dominant transmitter in the hypothalamus.
Decavel and van den Pol
J.Comp.Neurol., 1990;302:1019 -
GABAC receptors: relatively simple transmitter-gated ion channels?
Johnston
TiPS, 1996;17:319 -
GABA and its receptors in the spinal cord.
Malcangio and Bowery
TiPS, 1996;17:457
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Citations for GABA
The citations listed below are publications that use Tocris products. Selected citations for GABA include:
19 Citations: Showing 1 - 10
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Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo.
Authors: Bali Et al.
Sci Rep 2019;9:9324
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Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Authors: Nakano Et al.
Cell Rep 2019;27:860
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Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Authors: Garcia Et al.
Front Neurosci 2019;13:669
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Structure of a human synaptic GABAA receptor.
Authors: Zhu
Nature 2018;559(7712):67
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The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
Authors: David-Pereira
Neuroscience 2017;349:341
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FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
Authors: Lecat-Guillet Et al.
Cell Chem Biol 2017;24(3):360
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Increased GABAB receptor signaling in a rat model for schizophrenia
Authors: Selten Et al.
Scientific Reports 2016;6:34240
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γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Authors: Brown Et al.
J Biol Chem 2016;291:13926
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Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
Authors: Xia Et al.
PLoS One 2014;9:e100968
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Generation of induced neuronal cells by the single reprogramming factor ASCL1.
Authors: Chanda Et al.
Eur J Neurosci 2014;3:282
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Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
Authors: Diógenes Et al.
Cereb Cortex 2014;24:67
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Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
Authors: Fairless Et al.
PLoS One 2013;8:e58260
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GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
Authors: Fuchs Et al.
Evid Based Complement Alternat Med 2013;38:3146
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GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
Authors: Ring Et al.
PLoS One 2012;7:e36874
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Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.
Authors: Sciolino Et al.
Behav Brain Res 2012;233:191
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Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
Authors: Won Et al.
J Neurophysiol 2011;105:442
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Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.
Authors: Atherton Et al.
J Physiol 2008;586:5679
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GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Authors: Gascon Et al.
J Neurosci 2006;26:12956
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Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
Authors: Rundfeldt
Arzneimittelforschung 2000;50:1063
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