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GABA

Catalog #: 0344
19 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0344/1G
GABA | CAS No. 56-12-2 | GABA-A Receptor Agonists
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Description: Endogenous agonist

Chemical Name: γ-Aminobutyric acid

Product Details
Citations (19)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GABA is a GABA receptor agonist and endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).

Technical Data

M.Wt:
103.12
Formula:
C4H9NO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
56-12-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
    T Pérez-Bere, J Pujo, P Martin, P Le Faouder, JM Galano, A Guy, C Knauf, JC Tabet, S Tronnet, F Barreau, M Heuillet, G Dietrich, J Bertrand-M, T Durand, E Oswald, N Cenac
    Nat Commun, 2017;8(1):1314.
  2. miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis
    M Diepenbruc, S Tiede, M Saxena, R Ivanek, RKR Kalathur, F Lüönd, N Meyer-Scha, G Christofor
    Nat Commun, 2017;8(1):1168.
  3. GABA, bicuculline and central inhibition.
    Curtis et al.
    Nature, 1970;226:1222
  4. GABA: a dominant transmitter in the hypothalamus.
    Decavel and van den Pol
    J.Comp.Neurol., 1990;302:1019
  5. GABAC receptors: relatively simple transmitter-gated ion channels?
    Johnston
    TiPS, 1996;17:319
  6. GABA and its receptors in the spinal cord.
    Malcangio and Bowery
    TiPS, 1996;17:457

Product Datasheets

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Citations for GABA

The citations listed below are publications that use Tocris products. Selected citations for GABA include:

19 Citations: Showing 1 - 10

  1. Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo.
    Authors: Bali Et al.
    Sci Rep  2019;9:9324
  2. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
    Authors: Nakano Et al.
    Cell Rep  2019;27:860
  3. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  4. Structure of a human synaptic GABAA receptor.
    Authors: Zhu
    Nature  2018;559(7712):67
  5. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience  2017;349:341
  6. FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
    Authors: Lecat-Guillet Et al.
    Cell Chem Biol  2017;24(3):360
  7. Increased GABAB receptor signaling in a rat model for schizophrenia
    Authors: Selten Et al.
    Scientific Reports  2016;6:34240
  8. γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
    Authors: Brown Et al.
    J Biol Chem  2016;291:13926
  9. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  10. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    Eur J Neurosci  2014;3:282
  11. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
    Authors: Diógenes Et al.
    Cereb Cortex  2014;24:67
  12. Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
    Authors: Fairless Et al.
    PLoS One  2013;8:e58260
  13. GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
    Authors: Fuchs Et al.
    Evid Based Complement Alternat Med  2013;38:3146
  14. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  15. Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.
    Authors: Sciolino Et al.
    Behav Brain Res  2012;233:191
  16. Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
    Authors: Won Et al.
    J Neurophysiol  2011;105:442
  17. Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.
    Authors: Atherton Et al.
    J Physiol  2008;586:5679
  18. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
    Authors: Gascon Et al.
    J Neurosci  2006;26:12956
  19. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
    Authors: Rundfeldt
    Arzneimittelforschung  2000;50:1063

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