G-36

Catalog #: 4759
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4759/10

G-36 | CAS No. 1392487-51-2 | Estrogen and Related Receptor Antagonists

1 Image

Description: Selective GPER antagonist

Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

Purity: ≥99%

View All Products for Estrogen and Related Receptor Antagonists

Product Details

Citations (3)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC₅₀ = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Technical Data

M.Wt:

412.33

Formula:

C₂₂H₂₂BrNO₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at -20°C

CAS No:

1392487-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The G-protein-coupled estrogen receptor GPER in health and disease.
Prossnitz and Barton
Nat.Rev.Endocrinol., 2011;7:715
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
Dennis et al.
J.Steroid Biochem.Mol.Biol., 2011;127:358

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for G-36

The citations listed below are publications that use Tocris products. Selected citations for G-36 include:

3 Citations: Showing 1 - 3

Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats.
Authors: Jing Et al.
Biology (Basel) 2023;12
G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
Authors: Bin Et al.
J Neuroinflammation 2020;17:45
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Authors: Meseke Et al.
Eneuro 2018;5

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for G-36

There are currently no reviews for this product. Be the first to review G-36 and earn rewards!

Have you used G-36?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.