Flupirtine maleate

Catalog #: 2867
2 Citations Datasheet / COA / SDS

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Flupirtine maleate | CAS No. 75507-68-5 | Non-selective/Other Potassium Channel Activators

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Description: KV7 channel activator; also GABAA modulator and indirect NMDA antagonist

Alternative Names: D 9998

Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Flupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates K_V7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA_A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Technical Data

M.Wt:

420.4

Formula:

C₁₅H₁₇FN₄O₂.C₄H₄O₄

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

≥98%

Storage:

Desiccate at +4°C

CAS No:

75507-68-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Deuterated analog also available

Background References

Concomitant facilitation of GABA_A receptors and K_V7 channels by the non-opioid analgesic flupirtine.
Klinger
Br.J.Pharmacol., 2012;166:1631
Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.
Osborne et al.
Gen.Pharmacol., 1998;30:255
The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.
Azad et al.
Neurosci.Lett., 2004;370:186
Molecular expression and pharmacological identification of a role for K_v7 channels in murine vascular reactivity.
Yeung et al.
Br.J.Pharmacol., 2007;151:758

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Citations for Flupirtine maleate

The citations listed below are publications that use Tocris products. Selected citations for Flupirtine maleate include:

2 Citations: Showing 1 - 2

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Authors: Sedivy Et al.
Am J Physiol Lung Cell Mol Physiol 2015;308:L48
Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Authors: Lee Et al.
Int J Mol Sci 2014;15:977

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