FK 228

Catalog # Availability Size / Price Qty
3515/1
FK 228 | CAS No. 128517-07-7 | Class I Histone Deacetylases Inhibitors
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Description: Potent and selective class I histone deacetylase inhibitor; antitumor
Alternative Names: Depsipeptide,FR 901228,Romidepsin

Chemical Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Romidepsin is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
540.7
Formula:
C24H36N4O6S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
128517-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FK 228

The citations listed below are publications that use Tocris products. Selected citations for FK 228 include:

4 Citations: Showing 1 - 4

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