Fenretinide

Catalog #: 1396
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1396/10
1396/50

Fenretinide | CAS No. 65646-68-6 | Additional Retinoic Acid Receptor Compounds

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Description: Synthetic retinoid; antiproliferative and antioxidant

Alternative Names: 4-HPR

Chemical Name: N-(4-Hydroxyphenyl)retinamide

Purity: ≥98%

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Product Details

Citations (6)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Fenretinide is a synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Technical Data

M.Wt:

391.55

Formula:

C₂₆H₃₃NO₂

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

65646-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Deuterated analog also available

Background References

Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat.
Le Doze et al.
Drug Metab.Dispos., 2000;28:205
Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide).
Takahashi
Biol.Pharm.Bull., 2000;23:222
Fenretinide and its relation to cancer.
Ulukaya and Wood
Cancer Treat.Rev., 1999;25:229

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Citations for Fenretinide

The citations listed below are publications that use Tocris products. Selected citations for Fenretinide include:

6 Citations: Showing 1 - 6

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Authors: Xie Et al.
Cell Stem Cell 2019;25:639
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Authors: Catanese Et al.
Autophagy 2019;15:1719
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.
Authors: Lancaster Et al.
Cell Metab 2018;27:1096
Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo.
Authors: Jung Et al.
EMBO Rep 2017;18:1150
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Authors: Seidensaal Et al.
Am J Pathol 2015;14:204
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175

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