Etifoxine hydrochloride

Catalog #: 3113 Datasheet / COA / SDS

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Etifoxine hydrochloride | CAS No. 56776-32-0 | Translocator Protein Ligands

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Description: Ligand of the translocator protein (TSPO); also GABAA receptor potentiator

Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride

Purity: ≥98%

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Biological Activity

Etifoxine hydrochloride is a potentiator of GABA_A receptor function in cultured neurons. Preferentially acts on β₂ or β₃ subunit-containing GABA_A receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Technical Data

M.Wt:

337.24

Formula:

C₁₇H₁₇ClN₂O.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

56776-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The modulatory effects of the anxiolytic etifoxine on GABA_A receptors are mediated by the β subunit.
Hamon et al.
Neuropharmacology, 2003;45:293

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