Home / Additional Nicotinic Receptor Agonists / (±)-Epibatidine

(±)-Epibatidine

Catalog #: 0684
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0684/10
(±)-Epibatidine | CAS No. 148152-66-3 | Additional Nicotinic Receptor Agonists
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Description: High affinity nAChR agonist

Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Technical Data

M.Wt:
208.69
Formula:
C11H13ClN2
Solubility:
Soluble to 5 mM in water and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
148152-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US Patent 5,314,899

Background References

  1. Epibatidine, a potent analgesic and nicotinic agonist.
    Badio and Daly
    Mol.Pharmacol., 1994;45:563
  2. Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors.
    Gerzarich et al.
    Mol.Pharmacol., 1995;48:774
  3. Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain.
    Marks et al.
    J.Pharmacol.Exp.Ther., 1998;285:377
  4. UB-165 implicates α4β2 nAChR in striatal DA release.
    Sharples et al.
    J.Neurosci., 2000;20:2783
  5. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity.
    Spande et al.
    J.Am.Chem.Soc., 1992;114:3475

Product Datasheets

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Citations for (±)-Epibatidine

The citations listed below are publications that use Tocris products. Selected citations for (±)-Epibatidine include:

3 Citations: Showing 1 - 3

  1. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.
    Authors: Noviello Et al.
    Cell  2021;184:2121
  2. The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens.
    Authors: Williams Et al.
    Br J Pharmacol  2007;150:906
  3. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.
    Authors: Beckel Et al.
    J Neurosci  2006;290:F103

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