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EMI 48

Catalog #: 7424 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7424/10
EMI 48 | CAS No. 34564-13-1 | EGF Receptor Inhibitors
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Description: Inhibitor of EGFR mutants

Chemical Name: 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one

Purity: ≥98%

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Biological Activity

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.

Technical Data

M.Wt:
348.4
Formula:
C21H20N2O3
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
34564-13-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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