dTAG-47

Catalog #: 7530 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
7530/5

dTAG-47 | CAS No. 2265886-81-3 | Active Degraders

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Description: Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity: ≥97%

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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

dTAG-47 is a degrader targeting mutant FKBP12^F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12^F36V fusion proteins in vitro and in vivo. dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. See also dTAG-13 and dTAG-7.

Negative control (Cat. No. 7531) also available.

FKBP12^F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in.

Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12^F36V are available from Addgene.

Technical Data

M.Wt:

1076.25

Formula:

C₅₉H₇₃N₅O₁₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

2265886-81-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under license from Dana-Farber Cancer Institute

Product Datasheets

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