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DSR 6434

Catalog #: 4809 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4809/10
4809/50
DSR 6434 | CAS No. 1059070-10-8 | Toll-like Receptor Agonists
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Description: Potent TLR7 agonist

Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one

Purity: ≥98%

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Biological Activity

DSR 6434 is a potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Technical Data

M.Wt:
400.48
Formula:
C19H28N8O2
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1059070-10-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.
    Adlard et al.
    Int.J.Cancer, 2014;135:820
  2. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
    Nakamura et al.
    Bioorg.Med.Chem.Lett., 2013;23:669
  3. In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer
    AH Negussie, AS Mikhail, JW Owen, N Hong, CJ Carlson, Y Tang, KP Carrow, M Mauda-Hava, AL Lewis, JW Karanian, WF Pritchard, BJ Wood
    Scientific Reports, 2022;12(1):21886.

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