DPDPE
Purity: ≥95%
Biological Activity
DPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.Technical Data
(Modifications: X = D-Pen, Disulfide bridge: 2-5)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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[D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites.
Clark et al.
Eur.J.Pharmacol., 1986;128:303 -
Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Chandrakumar et al.
J.Med.Chem., 1992;35:2928 -
Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat.
Fraser et al.
J.Pharmacol.Exp.Ther., 2000;295:1135
Product Datasheets
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Citations for DPDPE
The citations listed below are publications that use Tocris products. Selected citations for DPDPE include:
12 Citations: Showing 1 - 10
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Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Authors: Nasrallah Et al.
Cell Rep 2019;27:86
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Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Authors: Leroy Et al.
Neuron 2019;102:260
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Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein.
Authors: Dunning Et al.
J Neurochem 2016;137:518
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Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents.
Authors: Tsitoura Et al.
J Biol Chem 2015;290:7961
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Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
Authors: Largent-Milnes Et al.
J Pharmacol Exp Ther 2013;347:7
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Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
Authors: Leal Et al.
PLoS One 2013;305:H1246
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Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
Authors: Marti Et al.
Br J Pharmacol 2013;168:863
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Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
Authors: Morse Et al.
BMC Pharmacol Toxicol 2013;14:17
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Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
Authors: Morse Et al.
PLoS One 2011;6:e25643
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Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
Authors: Saloman Et al.
Am J Physiol Heart Circ Physiol 2011;190:379
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Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.
Authors: Niu Et al.
Neuroscience 2011;180:344
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Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection.
Authors: Peart Et al.
J Mol Cell Cardiol 2007;42:972
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