Domoic acid
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Purity: ≥95%
Biological Activity
Domoic acid is a kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The activation of glutamate receptors by kainic acid and domoic acid.
Hampson and Manalo
Nat.Toxins, 1998;6:153 -
The primary afferent depolarizing action of kainate in the rat.
Agrawal and Evans
Br.J.Pharmacol., 1986;87:345 -
Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus.
Debonnel et al.
Can.J.Physiol.Pharmacol., 1989;67:29 -
Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors.
Watkins et al.
Excitatory Amino Acids and Synaptic Plasticity. Ed, 1990;:49
Product Datasheets
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Citation for Domoic acid
The citations listed below are publications that use Tocris products. Selected citations for Domoic acid include:
1 Citation: Showing 1 - 1
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Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
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