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Docetaxel

Catalog #: 4056
10 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4056/10
4056/50
Docetaxel | CAS No. 114977-28-5 | Microtubule Binding Compounds
1 Image
Description: Microtubule stabilizer

Chemical Name: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Purity: ≥99%

Product Details
Citations (10)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Technical Data

M.Wt:
807.88
Formula:
C43H53NO14
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
114977-28-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Docetaxel: a review of its use in metastatic breast cancer.
    Lyseng-Williamson and Fenton
    Drugs, 2005;65:2513
  2. Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors.
    Ramaswamy and Puhalla
    Drugs Today (Barc), 2006;42:265

Product Datasheets

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Citations for Docetaxel

The citations listed below are publications that use Tocris products. Selected citations for Docetaxel include:

10 Citations: Showing 1 - 10

  1. Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer.
    Authors: Bonifacio Nicolás Et al.
    Int J Biol Sci  2023;19:1731-1747
  2. Retinoic acid receptor γ is a therapeutically targetable driver of growth and survival in prostate cancer.
    Authors: Geoffrey Et al.
    Cancer Rep (Hoboken)  2020;3:e1284
  3. CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death.
    Authors: Leslie V Et al.
    Cancer Cell Int  2019;19:26
  4. Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
    Authors: Mabe Et al.
    J Clin Invest  2018;128:4413
  5. Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer.
    Authors: Hui Et al.
    Oncotarget  2017;8:103744-103757
  6. A high-content image analysis approach for quantitative measurements of chemosensitivity in patient-derived tumor microtissues.
    Authors: Malin Et al.
    Sci Rep  2017;7:6600
  7. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021
  8. Antitumor activity of amidino-substituted benzimidazole and benzimidazo[1,2-a]quinoline derivatives tested in 2D and 3D cell culture systems.
    Authors: Karmen Et al.
    J Enzyme Inhib Med Chem  2016;31:1139-45
  9. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
    Authors: Kathawala Et al.
    Oncotarget  2015;6:510
  10. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study.
    Authors: Kathawala Et al.
    Mol Cancer Ther  2014;13:714

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Positive control for apoptosis
By Anonymous on 12/01/2017

Used as a control to induced apoptosis in cancer cell lines

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