Dexfenfluramine hydrochloride

Catalog #: 2695
4 Citations Datasheet / COA / SDS

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Dexfenfluramine hydrochloride | CAS No. 3239-45-0 | 5-HT Transporter Inhibitors

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Description: 5-HT reuptake inhibitor; also stimulates 5-HT release

Alternative Names: (+)-Fenfluramine

Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride

Purity: ≥95%

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Product Details

Citations (4)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

Technical Data

M.Wt:

267.72

Formula:

C₁₂H₁₆F₃N.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥95%

Storage:

Desiccate at RT

CAS No:

3239-45-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Influence of the 5-HT_2C receptor antagonist SB242,084 on behaviour produced by the 5-HT₂ agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine.
Higgins et al.
Br.J.Pharmacol., 2001;133:459
Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox.
Caccia et al.
Pharmacol.Biochem.Behav., 1997;57:851
Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice.
Bush et al.
Endocrine, 2006;29:375

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Citations for Dexfenfluramine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

4 Citations: Showing 1 - 4

Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
Authors: Rodríguez-Muñoz Et al.
Oncotarget 2018;9:23373
Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis
Authors: Lyons Et al.
The journal of Neuroscience 2016;36:7392
Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
Authors: Banas Et al.
Neuropsychopharmacology 2011;36:423
A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
Authors: Kiyasova Et al.
J Neurosci 2011;31:2756

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