Desmopressin
Purity: ≥95%
Biological Activity
Desmopressin is a synthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.Technical Data
(Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor.
Saito et al.
Biochem.Pharmacol., 1997;53:1711 -
Desmopressin and other synthetic vasopressin analogues in cancer treatment.
Gomez et al.
Bull.Cancer, 2006;93:E7 -
Vasopressin antagonists in polycystic kidney disease.
Torres
Semin.Nephrol., 2008;28:306
Product Datasheets
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Citation for Desmopressin
The citations listed below are publications that use Tocris products. Selected citations for Desmopressin include:
1 Citation: Showing 1 - 1
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Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors.
Authors: Campos-Lira Et al.
Front Neurosci 2019;12:919
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