Deschloroclozapine
Chemical Name: 11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥98%
Biological Activity
Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (Ki values are 6.3 nM for hM3Dq and 4.2 nM for hM4Di, in vitro; EC50 values are 0.13 nM for hM3Dq and 0.081 nM for hM4Di, in vitro). Derivative of clozapine (Cat. No. 0444). Exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide (CNO; Cat. No. 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat. No. 5548). Displays low 'off-target' receptor binding (Ki >100 nM at majority of GPCRs, ion channels and transporters tested). Displays rapid (approx. 10 minutes after i.p injection) binding and activation of hM3Dq and hM4Di in mice and non-human primates. Induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Nagai et al.
Nat.Neurosci., 2020;23:1157
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Citation for Deschloroclozapine
The citations listed below are publications that use Tocris products. Selected citations for Deschloroclozapine include:
1 Citation: Showing 1 - 1
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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
Authors: David E Et al.
Cell 2022;185:3390-3407.e18
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