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Deltarasin

Catalog #: 5424
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5424/10
Deltarasin | CAS No. 1440898-82-7 | Other Ras GTPase Compounds
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Description: High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor (Kd = 41 nM); binds to PDEδ. Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

Technical Data

M.Wt:
713.14
Formula:
C40H37N5O.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1440898-82-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Deltarasin

The citations listed below are publications that use Tocris products. Selected citations for Deltarasin include:

2 Citations: Showing 1 - 2

  1. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.
    Authors: Malcolm G Et al.
    Nat Commun  2022;13:2791
  2. An In Vivo Inflammatory Loop Potentiates KRAS Blockade.
    Authors: Rudolf A Et al.
    Biomedicines  2022;10

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