DC 260126

Catalog #: 5357 Datasheet / COA / SDS

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DC 260126 | CAS No. 346692-04-4 | Free Fatty Acid Receptor Antagonists

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Description: FFA1 (GPR40) antagonist

Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide

Purity: ≥98%

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Biological Activity

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca²⁺ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Technical Data

M.Wt:

307.38

Formula:

C₁₆H₁₈FNO₂S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

346692-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats.
Zhang et al.
Biomed.Pharmacother., 2010;64:647
A novel class of antagonists for the FFAs receptor GPR40.
Hu et al.
Biochem.Biophys.Res.Comm., 2009;390:557
DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.
Sun et al.
PLoS ONE, 2013;8:e66744

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