DAU 5884 hydrochloride
Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
Purity: ≥99%
Biological Activity
DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of muscarinic receptors in guinea-pig uterus.
Doods et al.
Eur.J.Pharmacol., 1993;250:223 -
Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors.
Roffel et al.
Eur.J.Pharmacol., 1993;250:267 -
Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle.
Gosens et al.
Am.J.Respir.Cell Mol.Biol., 2003;28:257 -
Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype.
Gosens et al.
Br.J.Pharmacol., 2004;141:943
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Citation for DAU 5884 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DAU 5884 hydrochloride include:
1 Citation: Showing 1 - 1
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Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
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