DADLE

Catalog # Availability Size / Price Qty
3790/5
DADLE
1 Image
Description: Prototypical δ agonist
Alternative Names: [D-Ala2,D-Leu5]-Enkephalin

Purity: ≥95%

Product Details
Citations (4)
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Biological Activity

DADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data

M.Wt:
569.66
Formula:
C29H39N5O7
Sequence:
YAGFL

(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
63631-40-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain.
    Mulder et al.
    Br.J.Pharmacol., 1991;102:518
  2. Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
    Ke et al.
    Brain Res., 2009;1292:100
  3. Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
    Suh and Tseng
    Naunyn-Schmied.Arch.Pharmacol., 1990;342:67

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Citations for DADLE

The citations listed below are publications that use Tocris products. Selected citations for DADLE include:

4 Citations: Showing 1 - 4

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