D 4476

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
   Jaras M, Miller P, Chu L, Puram R, Fink E, Schneider R, Al-Shahrour F, Pena P, Breyfogle L, Hartwell K, McConkey M, Cowley G, Root D, Kharas M, Mullally A, Ebert B
   J Exp Med, 2014;211(4):605-12.
2. The selectivity of protein kinase inhibitors: a further update.
   Bain et al.
   Biochem.J., 2007;408:297
3. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
   Rena et al.
   EMBO Rep., 2004;5:60
4. Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5).
   Callahan et al.
   J.Med.Chem., 2002;45:999

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