Cytosporone B
Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Purity: ≥98%
Biological Activity
Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Zhan et al.
Nat.Chem.Biol., 2008;4:548 -
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
Palumbo-Zerr et al.
Nat.Med., 2015;21:150
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Citation for Cytosporone B
The citations listed below are publications that use Tocris products. Selected citations for Cytosporone B include:
1 Citation: Showing 1 - 1
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Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts.
Authors: Mircea Et al.
Am J Physiol Gastrointest Liver Physiol 2021;321:G280-G297
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