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Cytochalasin B

Catalog #: 5474
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5474/10
Cytochalasin B | CAS No. 14930-96-2 | Actin-related Products
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Description: Inhibitor of actin polymerization

Chemical Name: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione

Purity: ≥98%

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cytochalasin B is an inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.

Technical Data

M.Wt:
479.61
Formula:
C29H37NO5
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
14930-96-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cytochalasin B

The citations listed below are publications that use Tocris products. Selected citations for Cytochalasin B include:

7 Citations: Showing 1 - 7

  1. Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
    Authors: Stefanie M Et al.
    Mol Neurodegener  2023;18:15
  2. Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances.
    Authors: David Ian Et al.
    Arch Toxicol  2022;96:1455-1471
  3. WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues.
    Authors: Ingrid Et al.
    Dev Cell  2022;57:47-62.e9
  4. ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.
    Authors: Maria F Et al.
    Elife  2021;10
  5. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
    Authors: Zheng Et al.
    Cell Rep  2019;28:3224-3237.e5
  6. Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
    Authors: Bernier Et al.
    Cell Rep  2019;27:2895
  7. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.
    Authors: Diaz-Garcia Et al.
    Cell Metab  2017;26:361

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