Home / Sphingosine-1-phosphate Receptor Agonists / CYM 5520

CYM 5520

Catalog #: 5418
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5418/50
5418/10
CYM 5520 | CAS No. 1449747-00-5 | Sphingosine-1-phosphate Receptor Agonists
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Description: Selective S1P2 allosteric agonist

Chemical Name: 1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CYM 5520 is a selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.

Technical Data

M.Wt:
345.39
Formula:
C21H19N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1449747-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A sphingosine 1-phosphate receptor 2 selective allosteric agonist.
    Satsu et al.
    Bioorg.Med.Chem., 2013;21:5373

Product Datasheets

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Reconstitution Calculator

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Citations for CYM 5520

The citations listed below are publications that use Tocris products. Selected citations for CYM 5520 include:

2 Citations: Showing 1 - 2

  1. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
    Authors: Balaji M Et al.
    J Biol Chem  2021;296:100386
  2. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
    Authors: Matsushima-Nishiwaki Et al.
    PLoS One  2018;13:e0209050

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