Cyclosporin H
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Description: Enhances lentiviral transduction
Chemical Name: 5-(N-Methyl-D-valine)cyclosporin A
Purity: ≥97%
Biological Activity
Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).Technical Data
M.Wt:
1202.64
Formula:
C62H111N11O12
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
83602-39-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells.
Petrillo et al.
Cell Stem Cell., 2018;23:820
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