Cyclopiazonic acid

Catalog # Availability Size / Price Qty
1235/10
1235/50
Cyclopiazonic acid | CAS No. 18172-33-3 | Ca2+-ATPase Inhibitors
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Description: Inhibitor of SERCA ATPase
Alternative Names: α-Cyclopiazonic acid

Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

Purity: ≥98%

Product Details
Citations (16)
Reviews

Biological Activity

Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.

Technical Data

M.Wt:
336.39
Formula:
C20H20N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
18172-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cyclopiazonic acid

The citations listed below are publications that use Tocris products. Selected citations for Cyclopiazonic acid include:

16 Citations: Showing 1 - 10

  1. The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
    Authors: Dwivedi Et al.
    Eur J Pharmacol  2023;
  2. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
    Authors: Atakpa Et al.
    Cell Rep  2018;25:3180
  3. Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes.
    Authors: Morais Et al.
    Front Mol Neurosci  2018;10:444
  4. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  5. Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated Ins secretion.
    Authors: Li Et al.
    Cell Death Dis  2016;7:e2275
  6. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    Neuropharmacology  2015;9:6
  7. Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.
    Authors: Zhu Et al.
    Am J Physiol Cell Physiol  2015;308:C608
  8. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    J Neurosci  2015;10:e0121634
  9. Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging.
    Authors: McQuail Et al.
    Cardiovasc Res  2013;70:63
  10. Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.
    Authors: Alzayady Et al.
    J Biol Chem  2013;288:11122

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