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Cultrex Mouse Laminin I, Pathclear

Catalog #: 3400-010-02
22 Citations Datasheet / COA / SDS
Mouse Laminin I purified and qualified for use in cell culture
Catalog # Availability Size / Price Qty
3400-010-02
Product Details
Citations (22)
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Cultrex Mouse Laminin I, Pathclear Summary

Cultrex Mouse Laminin I, Pathclear is a purified basement membrane protein that has been developed and qualified as a extracellular matrix coating solution for cell attachment to tissue culture vessels.
 

Key Benefits

• Produced and qualified for use in cell culture
• Pathclear-tested to ensure a pathogen and virus-free material
• Source tissue is LDEV-free

Why Use Cultrex Mouse Laminin I?

Cultrex Mouse Laminin I, Pathclear is purified from Engelbreth-Holm-Swarm (EHS) tumor and is Pathclear-certified to be free of common pathogens. Laminin I is a major component of the basement membrane which is a continuous sheet of specialized extracellular matrix that forms an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that plays an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation.

Negative for the presence of bacteria and fungi.

Specifications

Source
Murine Engelbreth-Holm-Swarm (EHS) tumor
Sterility Testing
No bacterial or fungal growth detected following 14 days in culture
Testing Cell Culture
Supports cell attachment and spreading of MG63 human osteosarcoma cells.
Viral Testing
Tested negative by PCR test for a total of 31 organisms and viruses, including: mycoplasma, 17 bacterial and virus strains typically included in mouse antibody production (MAP) testing, and 13 additional murine infectious agents including LDEV.
Stability
Product is stable for a minimum of 3 months from date of shipment. See lot specific Certificate of Analysis for expiration date.
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Species
Mouse

Limitations

For research use only. Not for diagnostic use.

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Citations for Cultrex Mouse Laminin I, Pathclear

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

22 Citations: Showing 1 - 10
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  1. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
    Authors: Feringa, FM;Hertog, SJK;Wang, L;Derks, RJE;Kruijff, I;Erlebach, L;Heijneman, J;Miramontes, R;Pömpner, N;Blomberg, N;Olivier-Jimenez, D;Johansen, LE;Cammack, AJ;Giblin, A;Toomey, CE;Rose, IVL;Yuan, H;Ward, M;Isaacs, AM;Kampmann, M;Kronenberg-Versteeg, D;Lashley, T;Thompson, LM;Ori, A;Mohammed, Y;Giera, M;van der Kant, R;
    bioRxiv : the preprint server for biology  2024-07-03
  2. Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system
    Authors: Badja, C;Momen, S;Koh, GCC;Boushaki, S;Roumeliotis, TI;Kozik, Z;Jones, I;Bousgouni, V;Dias, JML;Krokidis, MG;Young, J;Chen, H;Yang, M;Docquier, F;Memari, Y;Valcarcel-Zimenez, L;Gupta, K;Kong, LR;Fawcett, H;Robert, F;Zhao, S;Degasperi, A;Kumar, Y;Davies, H;Harris, R;Frezza, C;Chatgilialoglu, C;Sarkany, R;Lehmann, A;Bakal, C;Choudhary, J;Fassihi, H;Nik-Zainal, S;
    Cell reports  2024-05-27
  3. Generation of human cerebral organoids with a structured outer subventricular zone
    Authors: Walsh, RM;Luongo, R;Giacomelli, E;Ciceri, G;Rittenhouse, C;Verrillo, A;Galimberti, M;Bocchi, VD;Wu, Y;Xu, N;Mosole, S;Muller, J;Vezzoli, E;Jungverdorben, J;Zhou, T;Barker, RA;Cattaneo, E;Studer, L;Baggiolini, A;
    Cell reports  2024-04-05
  4. 2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer
    Authors: Coy, S;Cheng, B;Lee, JS;Rashid, R;Browning, L;Xu, Y;Chakrabarty, SS;Yapp, C;Chan, S;Tefft, JB;Scott, E;Spektor, A;Ligon, KL;Baker, GJ;Pellman, D;Sorger, PK;Santagata, S;
    bioRxiv : the preprint server for biology  2023-11-11
  5. Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release
    Authors: You, W;Zhou, T;Knoops, K;Berendschot, TTJM;van Zandvoort, MAMJ;Germeraad, WTV;Benedikter, B;Webers, CAB;Reutelingsperger, CPM;Gorgels, TGMF;
    Scientific reports  2023-07-08
  6. In vitro myelination using explant culture of dorsal root ganglia: An efficient tool for analyzing peripheral nerve differentiation and disease modeling
    Authors: Numata-Uematasu, Y;Wakatsuki, S;Kobayashi-Ujiie, Y;Sakai, K;Ichinohe, N;Araki, T;
    PloS one  2023-05-24
  7. Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma
    Authors: RM Samuel, A Navickas, A Maynard, EA Gaylord, K Garcia, S Bhat, H Majd, MN Richter, N Elder, D Le, P Nguyen, B Shibata, ML Llabata, L Selleri, DJ Laird, S Darmanis, H Goodarzi, F Fattahi
    bioRxiv : the preprint server for biology, 2023-03-07;0(0):.  2023-03-07
  8. Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature
    Authors: L Taylor, PK Wade, JEC Johnson, M Aldighieri, S Morlando, G Di Leva, ID Kerr, B Coyle
    Cancers, 2023-02-08;15(4):.  2023-02-08
  9. Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
    Authors: JH Pham, GA Johnson, RS Rangan, CE Amankwa, S Acharya, DL Stankowska
    Cells, 2022-11-23;11(23):.  2022-11-23
  10. Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells
    Authors: W You, TTJM Berendscho, K Knoops, MAMJ van Zandvo, CAB Webers, CPM Reutelings, TGMF Gorgels
    International Journal of Molecular Sciences, 2022-02-28;23(5):.  2022-02-28
  11. Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function
    Authors: P Schiappare, NL Pirman, K Mohler, PA Miranda-He, N Zarco, O Kilic, C Miller, SR Shah, S Rogulina, W Hungerford, L Abriola, D Hoyer, BE Turk, H Guerrero-C, FJ Isaacs, A Quiñones-H, A Levchenko, J Rinehart
    Cell Reports, 2021-07-20;36(3):109416.  2021-07-20
  12. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
    Authors: J Piao, S Zabierowsk, BN Dubose, EJ Hill, M Navare, N Claros, S Rosen, K Ramnarine, C Horn, C Fredrickso, K Wong, B Safford, S Kriks, A El Maarouf, U Rutishause, C Henchcliff, Y Wang, I Riviere, S Mann, V Bermudez, S Irion, L Studer, M Tomishima, V Tabar
    Cell Stem Cell, 2021-02-04;28(2):217-229.e7.  2021-02-04
  13. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.  2020-06-19
  14. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.  2020
  15. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control
    Authors: S Ghatak, N Dolatabadi, D Trudler, X Zhang, Y Wu, M Mohata, R Ambasudhan, M Talantova, SA Lipton
    Elife, 2019-11-29;8(0):.  2019-11-29
  16. The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor
    Authors: JM Aye, LL Stafman, AP Williams, EF Garner, JE Stewart, JC Anderson, S Mruthyunja, MG Waldrop, CD Goolsby, HR Markert, C Quinn, R Marayati, E Mroczek-Mu, CD Willey, KJ Yoon, KF Whelan, EA Beierle
    Oncotarget, 2019-09-17;10(53):5534-5548.  2019-09-17
  17. Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts
    Authors: LL Stafman, AP Williams, R Marayati, JM Aye, HR Markert, EF Garner, CH Quinn, SB Lallani, JE Stewart, KJ Yoon, K Whelan, EA Beierle
    Sci Rep, 2019-09-13;9(1):13259.  2019-09-13
  18. A cell fitness selection model for neuronal survival during development
    Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
    Nat Commun, 2019-09-12;10(1):4137.  2019-09-12
  19. Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons
    Authors: RO Costa, H Martins, LF Martins, AW Cwetsch, M Mele, JR Pedro, D Tomé, NL Jeon, L Cancedda, SR Jaffrey, RD Almeida
    Cell Rep, 2019-07-23;28(4):864-876.e6.  2019-07-23
  20. Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
    Authors: M Plataki, L Fan, E Sanchez, Z Huang, LK Torres, M Imamura, Y Zhu, DE Cohen, SM Cloonan, AM Choi
    JCI Insight, 2019-07-09;5(0):.  2019-07-09
  21. Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics
    Authors: A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, JM Heo, LL Rubin, SS Sidhu, SP Gygi, JW Harper
    Mol. Cell, 2018-04-12;70(2):211-227.e8.  2018-04-12
  22. Amacrine cell subtypes differ in their intrinsic neurite growth capacity.
    Authors: Kunzevitzky N, Willeford K, Feuer W, Almeida M, Goldberg J
    Invest Ophthalmol Vis Sci, 2013-11-15;54(12):7603-13.  2013-11-15

FAQs

  1. What is the recommended working concentration for Cultrex Laminin I?

    • The recommended working concentration for thin coating is 0.05-10 µg/cm2 . However, conditions must be optimized for each cell line or model. Cultrex Laminin I should be used at 6 mg/mL for 3-D culture applications.

       

  2. Can Cultrex Mouse Laminin I be used on glass cover slips?

    • Yes. Coating glass cover slips with Cultrex Laminin I is quite common and has been published extensively.

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