CPYPP
Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity: ≥98%
Biological Activity
CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
Nishikimi et al.
Chem.Biol., 2012;19:488 -
Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
Laurin et al.
Proc.Natl.Acad.Sci.U.S.A., 2013;110:7434
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Citation for CPYPP
The citations listed below are publications that use Tocris products. Selected citations for CPYPP include:
1 Citation: Showing 1 - 1
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MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia.
Authors: Sayan Et al.
FASEB J 2019;33:5268-5286
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