CP 94253 hydrochloride
Chemical Name: 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Purity: ≥98%
Biological Activity
CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
Koe et al.
Drug Development Research, 1992;26:241 -
Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.
Fish et al.
Psychopharmacology, 1999;146:391 -
Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors.
Knobelman et al.
J.Pharmacol.Exp.Ther., 2000;292:1111
Product Datasheets
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Citations for CP 94253 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 94253 hydrochloride include:
7 Citations: Showing 1 - 7
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Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmacol 2020;175
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Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.
Authors: Mansari Et al.
Neuron 2015;232:2343
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5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.
Authors: Doslikova Et al.
J Neurosci 2013;33:9800
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Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
Authors: Eriksson Et al.
Psychopharmacology (Berl) 2013;18:1096
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5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes.
Authors: Hagan Et al.
Synapse 2012;66:1024
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Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior.
Authors: McDevitt Et al.
Pain 2011;69:780
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Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Authors: Heisler Et al.
Biol Psychiatry 2006;51:239
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