Cortistatin 14

Biological Activity

Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst₁ - sst₅) and prevents somatostatin-14 binding (IC₅₀ values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst₂, sst₄, sst₃, sst₅ and sst₁ receptors, respectively). Also a potent MRGPRX2 agonist (EC₅₀ = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland.
   Deghenghi et al.
   J.Endocrinol.Invest., 2001;24:RC1
2. Pharmacology and signaling of MAS-related G protein-coupled receptors.
   Solinski et al.
   Pharmacol.Rev., 2014;66:570

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