CKI 7 dihydrochloride
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity: ≥99%
Biological Activity
CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.
Osakada et al.
J.Cell Sci., 2009;122:3169 -
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
Rena et al.
EMBO Rep., 2004;5:60 -
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ.
Peifer et al.
J.Med.Chem., 2009;52:7618
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