Cirazoline hydrochloride
Chemical Name: 2-(2-Cyclopropylphenoxymethyl)imidazoline hydrochloride
Purity: ≥99%
Biological Activity
Cirazoline hydrochloride is a selective α1 agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats.
Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, Morton G, Schwartz M, Baskin D, Appleyard S, Blevins J
Endocrinology, 2014;155(8):2845-57. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats.
Gellai and Ruffolo
J.Pharmacol.Exp.Ther., 1987;240:723 -
Binding of [3H]cirazoline to an imidazoline site in rat brain and kidney membranes.
Le Rouzic et al.
Eur.J.Pharmacol., 1995;278:261 -
Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug.
Wikberg and Uklen
J.Neurochem., 1990;55:192
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Citations for Cirazoline hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Cirazoline hydrochloride include:
4 Citations: Showing 1 - 4
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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice.
Authors: Montgomery
Plos One 2017;12:e0168409
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The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
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PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle.
Authors: Bhattachariya Et al.
Physiol Rep 2014;2
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Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
Authors: Maupoil Et al.
Br J Pharmacol 2007;150:899
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