CID 2745687
Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
Purity: ≥98%
Biological Activity
CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
Jenkins et al.
J.Pharmacol.Exp.Ther., 2012;343:683 -
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
Zhao et al.
Mol.Pharmacol., 2010;78:560
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Citation for CID 2745687
The citations listed below are publications that use Tocris products. Selected citations for CID 2745687 include:
1 Citation: Showing 1 - 1
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Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.
Authors: Sun Et al.
Sci Rep 2014;4:4934
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