CGS 21680 hydrochloride

Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
Authors: Ledderose Et al.
Purinergic Signalling  2016;

Role of adenosine receptor subtypes in metha. reward and reinforcement.
Authors: Kavanagh Et al.
J Neurogenet  2015;89:265

Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death.
Authors: Tosolini Et al.
Psychopharmacology (Berl)  2015;35:479

Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
Authors: Kermanian Et al.
Eneuro  2015;28:120

On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
Authors: Wydra Et al.
Am J Respir Cell Mol Biol  2015;232:1767

Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
Mol Cell Biol  2015;2

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
Authors: Perez-Aso Et al.
Arthritis Res Ther  2015;17:249

Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission.
Authors: Ferreira Et al.
Br J Pharmacol  2015;172:1074

Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
Authors: Eusemann Et al.
PLoS One  2015;10:e0134934

Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
Authors: Ziemlinska Et al.
PLoS One  2014;9:e88833

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.
Authors: Ahsan and Mehal
Front Pharmacol  2014;5:69

IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Authors: Perígolo-Vicente Et al.
Biochem Biophys Res Commun  2014;449:477

Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
Authors: Ruby Et al.
Kidney Int  2014;39:2432

Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
Authors: Chen Et al.
J Neurosci  2014;34:9621

Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
Authors: Li Et al.
Vis Neurosci  2014;31:237

Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats.
Authors: O'Neill Et al.
Psychopharmacology (Berl)  2014;231:3179

Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
Authors: Welihinda and Amento
J Inflamm (Lond)  2014;11:37

Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
Authors: Xiao Et al.
PLoS One  2013;8:e60173

Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
Authors: Kozma Et al.
Biochem Pharmacol  2013;85:1171

DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
Authors: Fernández-Dueñas Et al.
FASEB J  2013;63:42

Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
Authors: Aggarwal Et al.
Neuropsychopharmacology  2013;48:635

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
Authors: Matos Et al.
J Neurosci  2013;33:18492

Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Authors: Yang Et al.
J Cereb Blood Flow Metab  2013;33:1612

Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Authors: Loram Et al.
Brain Behav Immun  2013;33:112

Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.
Authors: Bao Et al.
J Biol Chem  2013;288:22650

Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
Authors: Wiseman Et al.
J Biol Chem  2013;288:17803

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
Authors: He Et al.
FASEB J  2013;27:3446

Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
Authors: Thomas Et al.
Bioorg Med Chem  2013;21:7453

Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice.
Authors: Lee
J Immunol  2013;191:4103

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol  2013;169:1600

Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
Authors: Mills Et al.
J Neurochem  2012;9:193

Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
Authors: Kan Et al.
J Virol  2012;86:10338

Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
Authors: Park Et al.
Kidney Int  2012;82:878

When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
Authors: Lee Et al.
PLoS One  2012;7:e38865

Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats.
Authors: Hobson Et al.
Neuropharmacology  2012;63:1172

Adenosine A2A receptor activation prevents wear particle-induced osteolysis.
Authors: Mediero Et al.
Sci Transl Med  2012;4:135ra65

Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.
Authors: O'Neill Et al.
Neuropsychopharmacology  2012;37:1245

Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection.
Authors: Jeon Et al.
Neurochem Int  2012;20:27

Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.
Authors: Fernández-Dueñas Et al.
J Immunol  2012;123:373

Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Authors: Garcia Et al.
PLoS One  2011;80:378

Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.
Authors: Kiebala and Maggirwar
PLoS One  2011;6:e18633

Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.
Authors: Su Et al.
Cancer Immunol Immunother  2011;60:111

Adenosine-induced activation of esophageal nociceptors.
Authors: Ru Et al.
Am J Physiol Gastrointest Liver Physiol  2011;300:G485

Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase.
Authors: Carlström Et al.
Am J Physiol Renal Physiol  2011;300:F457

Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists.
Authors: Das Et al.
J Nanobiotechnology  2010;8:11

Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
Authors: Keene Et al.
Biochem Pharmacol  2010;80:188

Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Authors: Wang Et al.
Biomol Ther (Seoul)  2010;5:e13883

The A2aR adenosine receptor controls cytokine production in iNKT cells.
Authors: Nowak Et al.
Neuropharmacology  2010;40:682

Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
Authors: Hiranita Et al.
J Pharmacol Exp Ther  2010;332:515

Adenosine can mediate its actions through generation of reactive oxygen species.
Authors: Gebremedhin Et al.
J Cereb Blood Flow Metab  2010;30:1777

Competitive regulation of synaptic Ca²⁺ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci  2010;13:958

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Authors: Zhou Et al.
J Clin Invest  2010;120:2280

Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
Authors: Garavaglia Et al.
BMC Neurosci  2010;11:7

Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
Authors: Xi Et al.
J Mol Cell Cardiol  2009;47:684

Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
Authors: Epperson Et al.
Am J Physiol Cell Physiol  2009;296:C1171

A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments.
Authors: Ohta Et al.
Eur J Immunol  2009;183:5487

The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
Authors: Pugliese Et al.
Br J Pharmacol  2009;157:818

Dichotomous DArgic control of striatal synaptic plasticity.
Authors: Shen Et al.
Science  2008;321:848

Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.
Authors: Garcia Et al.
J Neuroinflammation  2008;22:445

Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.
Authors: Keir Et al.
Br J Pharmacol  2006;147:720

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
Authors: Yang Et al.
J Clin Invest  2006;116:1913

Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
Authors: Kornerup Et al.
Br J Pharmacol  2005;144:1011

Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
Authors: Germack and Dickenson
Br J Pharmacol  2004;141:329

Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Authors: Nieri Et al.
Br J Pharmacol  2001;134:745

Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release.
Authors: Ezeamuzie and Philips
Br J Pharmacol  1999;127:188