Cevimeline hydrochloride

Catalog #: 3689
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3689/10
3689/50

Cevimeline hydrochloride | CAS No. 107220-28-0 | mAChR M1 Agonists

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Description: Selective M1 agonist

Alternative Names: AF 102B,SNI 2011

Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride

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Product Details

Citations (1)

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Biological Activity

Cevimeline hydrochloride is a selective M₁ receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC₅₀ values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data

M.Wt:

235.77

Formula:

C₁₀H₁₇NOS.HCl

Solubility:

Soluble to 75 mM in water and to 50 mM in DMSO

Storage:

Store at -20°C

CAS No:

107220-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954.
Wanibuchi et al.
Eur.J.Pharmacol., 1990;187:479
(+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M₁ selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Fisher et al.
J.Pharmacol.Exp.Ther., 1991;257:392
L-689,660, a novel cholinomimetic with functional selectivity for M₁ and M₃ muscarinic receptors.
Hargreaves et al.
Br.J.Pharmacol., 1992;107:494

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Citation for Cevimeline hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Cevimeline hydrochloride include:

1 Citation: Showing 1 - 1

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex.
Authors: Pasko Et al.
Neuron 2020;106:649-661.e4

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