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Ceapin A7

Catalog #: 6955 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6955/10
6955/50
Ceapin A7 | CAS No. 2323027-38-7 | Other ER Stress/UPR Activators
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Description: Selective inhibitor of ATF6α; sensitizes cells to ER stress

Chemical Name: N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide

Purity: ≥98%

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Biological Activity

Ceapin A7 is a selective inhibitor of ATF6α (IC50=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.

Technical Data

M.Wt:
470.33
Formula:
C20H12F6N4O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2323027-38-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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