CDN 1163

Biological Activity

CDN 1163 is a SERCA2 allosteric activator. Increases Ca²⁺-ATPase activity and Ca²⁺ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective, improves memory and cognition in a mouse Alzheimer's disease model and reduces dyskinesia in rat model of Parkinson's disease. Orally bioavailable.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice.
   Krajnak and Dahl et al.
   Bioorg.Med.Chem.Lett., 2018;28:1591
2. Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) attenuates diabetes and metabolic disorders.
   Kang et al.
   J.Biol.Chem., 2016;291:5185

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