Home / p97 ATPase Inhibitors / CB 5083

CB 5083

Catalog #: 7379 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7379/5
7379/25
CB 5083 | CAS No. 1542705-92-9 | p97 ATPase Inhibitors
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Description: Potent p97 ATPase inhibitor

Chemical Name: 1-[7,8-Dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide

Purity: ≥98%

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Biological Activity

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC50 = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC50 = 680 nM) and reduces cell viablility in a range of colorectal cancer cell lines. Increases CHOP and GRP78 protein levels, upregulates PD-L1 mRNA levels and results in the loss of aggresomes.

Technical Data

M.Wt:
413.48
Formula:
C24H23N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1542705-92-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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