Castanospermine
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Biological Activity
Castanospermine is a potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Gruters et al.
Nature, 1987;330:74 -
Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases.
Saul et al.
Arch.Biochem.Biophys., 1984;230:668 -
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Welker et al.
Proc.Natl.Acad.Sci.U.S.A., 1987;84:8120
Product Datasheets
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Citation for Castanospermine
The citations listed below are publications that use Tocris products. Selected citations for Castanospermine include:
1 Citation: Showing 1 - 1
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The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
Authors: Nacev Et al.
J Biol Chem 2011;286:44045
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