Caspase-12 Inhibitor Z-ATAD-FMK Summary
Key Benefits
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
Specifications
Product Datasheets
Background: Caspase-12
Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
Citations for Caspase-12 Inhibitor Z-ATAD-FMK
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Phagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response
Authors: SH Kim, SN Cho, YJ Lim, JA Choi, J Lee, D Go, CH Song
Cell Biosci, 2018-09-29;8(0):52. 2018-09-29
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TNF-?-mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis
Authors: SM Oh, YJ Lim, JA Choi, J Lee, SN Cho, D Go, SH Kim, CH Song
FASEB J., 2018-02-26;0(0):fj201701407R. 2018-02-26
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Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
Proc Natl Acad Sci U S A, 2015-12-17;113(4):960-5. 2015-12-17
FAQs
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Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?
Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.
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Are R&D Systems Caspase Inhibitors irreversible?
Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.
R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.
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