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Caspase-1/ICE Inhibitor Z-WEHD-FMK

Catalog #: FMK002
32 Citations Datasheet / COA / SDS
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FMK002
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Citations (32)
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Summary Product Datasheets Background

Caspase-1/ICE Inhibitor Z-WEHD-FMK Summary

 

Key Benefits

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-1

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
834 (Human)
Alternate Names
CASP1 nirs variant 1; CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1 subunit p10; Caspase-1 subunit p20; Caspase1; Caspase-1; EC 3.4.22.36; EC:3.4.22.36; ICE; IL-1 beta-converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

Citations for Caspase-1/ICE Inhibitor Z-WEHD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

32 Citations: Showing 1 - 10
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  1. CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury
    Authors: PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh
    JCI Insight, 2022-09-01;0(0):.  2022-09-01
  2. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022-02-02;0(0):.  2022-02-02
  3. Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death
    Authors: RA Elrayess, ME Mohallal, YM Mobarak, HM Ebaid, S Haywood-Sm, K Miller, PN Strong, MA Abdel-Rahm
    Frontiers in Pharmacology, 2022-01-10;12(0):788874.  2022-01-10
  4. Human fetal membrane IL-1beta production in response to bacterial components is mediated by uric-acid induced NLRP3 inflammasome activation
    Authors: AS Miller, TN Hidalgo, VM Abrahams
    Journal of reproductive immunology, 2021-12-02;149(0):103457.  2021-12-02
  5. Caspase-1 Inhibition Impacts the Formation of Chondrogenic Nodules, and the Expression of Markers Related to Osteogenic Differentiation and Lipid Metabolism
    Authors: A Ramesova, B Vesela, E Svandova, H Lesot, E Matalova
    International Journal of Molecular Sciences, 2021-09-03;22(17):.  2021-09-03
  6. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
    Authors: C Xu, S Sun, T Johnson, R Qi, S Zhang, J Zhang, K Yang
    Cell Reports, 2021-06-15;35(11):109235.  2021-06-15
  7. NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells
    Authors: VM Abrahams, Z Tang, G Mor, S Guller
    J Reprod Immunol, 2020-10-03;142(0):103214.  2020-10-03
  8. NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia
    Authors: V Lavallard, D Cottet-Dum, CH Wassmer, C Rouget, G Parnaud, E Brioudes, F Lebreton, K Bellofatto, E Berishvili, T Berney, D Bosco
    Sci Rep, 2020-04-24;10(1):7011.  2020-04-24
  9. A Novel Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo
    Authors: S Talley, O Kalinina, M Winek, W Paik, AR Cannon, F Alonzo, MA Choudhry, KL Knight, EM Campbell
    J. Immunol., 2019-09-27;0(0):.  2019-09-27
  10. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
    Authors: B Corleis, AN Bucsan, M Deruaz, VD Vrbanac, AC Lisanti-Pa, SJ Gates, AH Linder, JM Paer, GS Olson, BA Bowman, AE Schiff, BD Medoff, AM Tager, AD Luster, SA Khader, D Kaushal, DS Kwon
    Cell Rep, 2019-02-05;26(6):1409-1418.e5.  2019-02-05
  11. Effects of metal ions on caspase-1 activation and interleukin-1? release in murine bone marrow-derived macrophages
    Authors: MA Ferko, I Catelas
    PLoS ONE, 2018-08-23;13(8):e0199936.  2018-08-23
  12. Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia
    Authors: N Gonzalez-J, KM Bradley, AN Riegler, LF Reyes, T Brissac, SS Park, MI Restrepo, CJ Orihuela
    Sci Rep, 2018-04-11;8(1):5846.  2018-04-11
  13. Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1?/TNFAIP3 Axis
    Authors: Y Kang, H Zhang, Y Zhao, Y Wang, W Wang, Y He, W Zhang, W Zhang, X Zhu, Y Zhou, L Zhang, Z Ju, L Shi
    Cell Rep, 2018-03-27;22(13):3493-3506.  2018-03-27
  14. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
    Authors: Z Czimmerer, B Daniel, A Horvath, D Rückerl, G Nagy, M Kiss, M Peloquin, MM Budai, I Cuaranta-M, Z Simandi, L Steiner, B Nagy, S Poliska, C Banko, Z Bacso, IG Schulman, S Sauer, JF Deleuze, JE Allen, S Benko, L Nagy
    Immunity, 2018-01-16;48(1):75-90.e6.  2018-01-16
  15. Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction
    Authors: KM Boini, T Hussain, PL Li, SS Koka
    Cell. Physiol. Biochem., 2017-11-06;44(1):152-162.  2017-11-06
  16. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation
    Authors: SN Cross, JA Potter, P Aldo, JY Kwon, M Pitruzzell, M Tong, S Guller, CV Rothlin, G Mor, VM Abrahams
    J. Immunol., 2017-09-15;0(0):.  2017-09-15
  17. Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
    Authors: LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton
    Cytokine, 2017-07-13;0(0):.  2017-07-13
  18. Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion
    Authors: R Dornhof, C Maschowski, A Osipova, R Gieré, M Seidl, I Merfort, M Humar
    PLoS ONE, 2017-07-03;12(7):e0180291.  2017-07-03
  19. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor
    Authors: R Soto, C Petersen, CL Novis, JL Kubinak, R Bell, WZ Stephens, TE Lane, RS Fujinami, A Bosque, RM O'Connell, JL Round
    Proc. Natl. Acad. Sci. U.S.A., 2017-05-09;0(0):.  2017-05-09
  20. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
    Sci Rep, 2016-12-15;6(0):37433.  2016-12-15
  21. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
    Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
    PLoS Pathog, 2015-12-11;11(12):e1005337.  2015-12-11
  22. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
    Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
    PLoS ONE, 2015-08-24;10(8):e0136708.  2015-08-24
  23. Spleen Tyrosine Kinase (Syk) Mediates IL-1beta Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
    Authors: Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J
    J Biol Chem, 2015-06-01;290(28):17306-20.  2015-06-01
  24. The flagellar regulator TviA reduces pyroptosis by Salmonella enterica serovar Typhi.
    Authors: Winter S, Winter M, Atluri V, Poon V, Romao E, Tsolis R, Baumler A
    Infect Immun, 2015-02-02;83(4):1546-55.  2015-02-02
  25. Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.
    Authors: Teigler J, Kagan J, Barouch D
    J Virol, 2014-07-02;88(18):10354-63.  2014-07-02
  26. Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
    Authors: Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P
    Am J Pathol, 2014-03-13;184(5):1617-28.  2014-03-13
  27. Leptin enhances the secretion of interleukin (IL)-18, but not IL-1beta, from human monocytes via activation of caspase-1.
    Authors: Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J
    Cytokine, 2013-11-23;65(2):222-30.  2013-11-23
  28. Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
    Authors: Mukherjee P, Woods T, Moore R, Peterson K
    Immunity, 2013-03-14;38(4):705-16.  2013-03-14
  29. Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells.
    Authors: Cho MH, Ahn HJ, Ha HJ, Park J, Chun JH, Kim BS, Oh HB, Rhie GE
    Infect. Immun., 2009-09-08;78(1):387-92.  2009-09-08
  30. Active caspase-1-mediated secretion of retinoic acid inducible gene-I.
    Authors: Kim, Min-Jung, Yoo, Joo-Yeon
    J Immunol, 2008-11-15;181(10):7324-31.  2008-11-15
  31. Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection.
    Authors: Jin H, Xiao C, Zhao G, Du X, Yu Y, Kang Y, Wang B
    J. Cell. Biochem., 2007-11-01;102(4):980-91.  2007-11-01
  32. RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
    Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
    Blood, 2004-02-24;103(11):4180-7.  2004-02-24

FAQs

  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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