C34

Catalog #: 5373
8 Citations Datasheet / COA / SDS

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5373/50

C34 | CAS No. 40592-88-9 | Toll-like Receptor Inhibitors

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Description: TLR4 inhibitor

Alternative Names: TLR4-IN-C34

Chemical Name: 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

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Product Details

Citations (8)

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Biological Activity

C34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

Technical Data

M.Wt:

389.4

Formula:

C₁₇H₂₇NO₉

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Storage:

Store at -20°C

CAS No:

40592-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.
Neal et al.
PLoS One, 2013;8:e65779

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Citations for C34

The citations listed below are publications that use Tocris products. Selected citations for C34 include:

8 Citations: Showing 1 - 8

Extracellular Nucleophosmin Is Increased in Psoriasis and Correlates With the Determinants of Cardiovascular Diseases.
Authors: Maurizio C Et al.
Front Cardiovasc Med 2022;9:867813
Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells.
Authors: Alessandro Et al.
BMC Biol 2021;19:124
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Authors: Nara Et al.
Sci Rep 2020;10:17451
Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation.
Authors: Minsoo Et al.
Cell Rep 2019;28:2923-2938.e8
CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
Authors: Zhang Et al.
BMC Immunol 2019;20:7
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Authors: Zhou Et al.
Oncol Lett 2019;18:181
Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner.
Authors: Stephens Et al.
Front Immunol 2019;10:557
Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner.
Authors: Sun Et al.
J Neuroinflammation 2017;14:231

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