Bumetanide
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Purity: ≥98%
Biological Activity
Bumetanide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Diuretic sensitive electroneutral Na(+) movement and temperature effects on central axons
M Kanagaratn, C Pendleton, DA Souza, J Pettit, J Howells, MD Baker
J. Physiol. (Lond.), 2017;0(0):. -
Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
O'Grady et al.
Am.J.Physiol., 1987;253:C177 -
Ion and bumet. binding by the Na-K-Cl cotransporter.
Isenring and Forbush
J.Biol.Chem., 1997;272:24556
Product Datasheets
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Citations for Bumetanide
The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:
12 Citations: Showing 1 - 10
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Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Authors: Babola Et al.
Elife 2020;9:e52160
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Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
Authors: Bhandage Et al.
Front Cell Infect Microbiol 2019;9:73
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KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
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Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
Authors: Alfonsa Et al.
Nature Communications 2016;7:13495
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Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Authors: Pál Et al.
Neuron 2015;8:35
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High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Authors: Choe Et al.
Mol Brain 2015;85:549
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A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Authors: Angelantonio Et al.
Cell Death Dis 2014;5:e1501
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Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
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GABA is excitatory in adult vasopressinergic neuroendocrine cells.
Authors: Haam Et al.
J Neurosci 2012;32:572
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The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
Authors: Shulga Et al.
J Neurosci 2012;32:1757
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Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Authors: Safiulina Et al.
J Physiol 2008;586:5437
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Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons.
Authors: Shulga Et al.
J Neurosci 2008;28:6996
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