BTT 3033
Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity: ≥98%
Biological Activity
BTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel a2�1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.
Nissinen et al.
J.Cell Biol., 2012;287:44694
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Citations for BTT 3033
The citations listed below are publications that use Tocris products. Selected citations for BTT 3033 include:
4 Citations: Showing 1 - 4
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How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.
Authors: Gertraud Et al.
Sci Adv 2023;9:eadd9275
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Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells.
Authors: Li Et al.
Ann.Transl.Med. 2021;9:1380
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Collagen I Fibrous Substrates Modulate the Proliferation and Secretome of Estrogen Receptor-Positive Breast Tumor Cells in a Hormone-Restricted Microenvironment.
Authors: Elaine T Et al.
ACS Biomater Sci Eng 2021;7:2430-2443
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Collagen Type 1 accelerates healing of ruptured fetal membranes.
Authors: Mogami
Sci Rep 2018;8(1):696
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